Predictive Sys-Bio Lab

Image: Fitness landscape for an objective function with multiple minima

What we do:

We are interested in how cells work at the systems levels, especially metabolic and protein signaling pathways.

The long term objectives of the labs are:

1. Develop techniques to create reliable quantitative mechanistic models of cellular pathways can could be useful in the clinic.

2. Develop computational tools and standards in qualitative systems biology.

Current Projects:

  • Leading the Center of Reproducibility in Biomedical Modeling.
  • Developing predictive mechanistic models of EGF signalling in cancer.
  • Developing high-performance computing environments for desktop and cluster environments.
  • Developing user tools for modeling and analysis of pathways.
  • developing new modeling strategies for complex systems.
  • Understanding the operational characteristics of cellular pathways.

Visit the Center for Reproducibility at:

We acknowledge generous support from a number of NIH Divisions and the NSF:

Past work supported by: